Prof. Dr. Bernhard Wünsch
Westfälische Wilhelms Universität Münster
Fachbereich: Chemie und Pharmazie
Zugeordnete Branche: Life Sciences und Gesundheit
Zugeordnetes Fachgebiet: Pharmazie
Institut: Institut für Pharmazeutische und Medizinische Chemie
The main focus is the development and synthesis of novel ligands for receptors in the Central Nervous System.
Of particular interest are:
- NMDA-receptors (PCP-binding site, NR1B/2B-subunit)
- Opioid-receptors (mü, kappa and delta)
- sigma-receptor (sigma1 and sigma2)
- Neurokinin-receptors
Synthesis of novel ligands:
- Stereoselective synthesis (asymmetric synthesis, diastereoselective synthesis, chiral-pool-Synthesis)
- Application of enzymes for stereoselective synthesis
Receptor affinity:
- Determination of the receptor affinity by performing competition experiments with selective, tritium-labelled reference compounds (in vitro)
- Structure-affinity-relationships
Systematic optimization of the ligands:
- Molecular modelling
Westfälische Wilhelms Universität Münster
Corrensstraße 48 | 48149 Münster
Tel. 0251 - 83-33310
